1-(6-fluoropyridin-2-yl)piperazine → N-(1-(4-(1-(4-(6-fluoropyridin-2-yl)piperazin-1-yl)ethyl)phenyl)-1-methylethyl)acetamide

HRID 1282200Notes

Reaction equation

HRID 1282200 reaction equation
[F:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:5]=[CH:4][CH:3]=1.Cl[CH:15]([C:17]1[CH:22]=[CH:21][C:20]([C:23]([NH:26][C:27](=[O:29])[CH3:28])([CH3:25])[CH3:24])=[CH:19][CH:18]=1)[CH3:16]>>[F:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:13][CH2:12][N:11]([CH:15]([C:17]3[CH:22]=[CH:21][C:20]([C:23]([NH:26][C:27](=[O:29])[CH3:28])([CH3:25])[CH3:24])=[CH:19][CH:18]=3)[CH3:16])[CH2:10][CH2:9]2)[CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 37288181-(6-fluoropyridin-2-yl)piperazineHCID 18423053N-(1-(4-(1-chloroethyl)phenyl)-1-methylethyl)acetamide

Product 1

HCID 11509254N-(1-(4-(1-(4-(6-fluoropyridin-2-yl)piperazin-1-yl)ethyl)phenyl)-1-methylethyl)acetamide

Procedure

By similar reaction and treatment to that in Example 1(5) using 1-(6-fluoropyridin-2-yl)piperazine obtained in Example 85(2) instead of phenylpiperazine and N-(1-(4-(1-chloroethyl)phenyl)-1-methylethyl)acetamide instead of N-(4-chloromethylphenylmethyl)acetamide, the title compound can be obtained.

Workup

  1. customBy similar reaction and treatment to that in Example

Sources & evidence

ORD record
ord-f8766c8af7ba427184a3ddf8ae84a654
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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