5-Chloro-2-methylphenyl isothiocyanate → HCID 9815210, compound

HRID 1282211Notes

Reaction equation

HRID 1282211 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:11])=[C:6]([N:8]=[C:9]=[S:10])[CH:7]=1.[NH2:12][C:13]1[S:14][C:15]([CH3:19])=[C:16]([CH3:18])[N:17]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:11])=[C:6]([NH:8][C:9]([NH:12][C:13]2[S:14][C:15]([CH3:19])=[C:16]([CH3:18])[N:17]=2)=[S:10])[CH:7]=1

Participants

3

Reactant 2

HCID 295195-Chloro-2-methylphenyl isothiocyanateHCID 732382-Amino-4,5-dimethyl-1,3-thiazole

Product 1

HCID 9815210HCID 9815210, compoundYield 31.4%

Procedure

Prepared using Method B from 4.5 g (24.5 mmol) of 5-chloro-2-methyl-phenyl isothiocyanate and 2.79 g (24.5 mmol) of 2-amino-4,5-dimethylthiazole to give 2.4 g of title compound as a white solid (31% yield, m.p. 188-189° C.).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-f442c5de00c440adb6f16fecb12c7583
Source dataset
uspto-grants-2002_09
Patent number
US06455566B1

Reaction notes

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