HCID 18761594, compound → HCID 86588385, compound

HRID 1282322Notes

Reaction equation

HRID 1282322 reaction equation
C(C1C=CC(C#C)=CC=1OC1C=CC(C)=CC=1)(C)(C)C.[C:21]([C:25]1[CH:30]=[CH:29][C:28]([C:31]#[C:32][Si](C)(C)C)=[CH:27][C:26]=1[O:37][C:38]1[CH:43]=[CH:42][C:41]([CH2:44][CH3:45])=[CH:40][CH:39]=1)([CH3:24])([CH3:23])[CH3:22]>>[C:21]([C:25]1[CH:30]=[CH:29][C:28]([C:31]#[CH:32])=[CH:27][C:26]=1[O:37][C:38]1[CH:43]=[CH:42][C:41]([CH2:44][CH3:45])=[CH:40][CH:39]=1)([CH3:23])([CH3:24])[CH3:22]

Participants

3

Reactant 2

HCID 18761594HCID 18761594, compound2×HCID 86588386HCID 86588386, compound2×

Product 1

HCID 86588385HCID 86588385, compound

Procedure

Employing the same general procedure as for the preparation of 2-tert-butyl-5-ethynyl-1-[(4′-methyl)phenoxy]benzene (Compound W), 40 mg (0.1 mmol) 2-tert-butyl-5-trimethylsilanylethynyl-1-[(4′-ethyl)phenoxy]benzene (Compound V) was converted into the title compound using 4.3 mg (0.03 mmol) of potassium carbonate, 3 mL of methanol and 1 mL of dichloromethane. Purification by flash chromatography (silica, 100% hexane) gave the title compound as a clear, yellow oil.

Sources & evidence

ORD record
ord-d4302aa149834f659257b23827b4eb4b
Source dataset
uspto-grants-2002_09
Patent number
US06455701B1

Reaction notes

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