反应详情

Ethyl chloroformate (1.05 ml, 0.011 mol) was added dropwise to a stirred solution of 2-amino-4-methyloxazole (1.0 g, 0.010 mol) and triethylamine (1.5 ml, 0.011 mol) in dry ether (50 ml) at 5°-10° C. The mixture was stirred for 2 hours at 0°-5° C. then the white solid was filtered off and washed well with water to remove triethylamine hydrochloride. Residue (0.5 g) was recrystallised from chloroform-petroleum spirit, m.p. 126° C.

1. filtrationthe white solid was filtered off
2. washwashed well with water
3. customto remove triethylamine hydrochloride
4. customResidue (0.5 g) was recrystallised from chloroform-petroleum spirit, m.p. 126° C.