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HRID1282365

反应详情

EQUATION

反应方程式

HRID 1282365 的结构方程式

REACTANTS

反应物

4
结构：CS(C)=O
HCID679

Dimethyl sulfoxide

C2H6OS

2 次

结构：CI
HCID6328

Methyl iodide

CH3I

结构：[H-].[Na+]
HCID24758

Sodium hydride

HNa

结构：CCOC(=O)Cc1cc(C)c(C(=O)c2ccc(Cl)cc2)n1C
HCID118463

Ethyl 5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrole-2-acetate

C17H18ClNO3

PRODUCTS

生成物

1
结构：CCOC(=O)C(C)c1cc(C)c(C(=O)c2ccc(Cl)cc2)n1C
HCID118464

Ethyl 2-[5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-yl]propanoate

C18H20ClNO3

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

6.4 grams (0.02 mole) of ethyl 5-(p-chlorobenzoyl)-1,4-dimethylpyrrole-2-acetate is dissolved in 100 ml. of dimethyl sulfoxide (DMSO) and added to a slurry of 0.48 g. (0.02 mole) of sodium hydride in approximately 30 ml. of DMSO. The mixture is stirred for 30 minutes before 2.84 g. (0.02 mole) of methyl iodide is added. Stirring is continued for 15 minutes. The reaction mixture is then poured into water, and the precipitate filtered off and recrystallized from 2-propanol to yield ethyl 5-(p-chlorobenzoyl)-1,4,α-trimethylpyrrole-2-acetate, m.p. 88-90° C.

WORKUP

后处理

  1. stirringStirring
  2. waitis continued for 15 minutes
  3. filtrationthe precipitate filtered off
  4. customrecrystallized from 2-propanol