1-Iodopropane → HCID 86584045, compound

HRID 1282380Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:21]=[CH:22][C:23]=1[O:24][CH3:25])[C:6]([C:8]1[N:12]([CH3:13])[C:11]([CH2:14][C:15]([O:17]CC)=[O:16])=[CH:10][C:9]=1[CH3:20])=[O:7].C(I)CC>>[CH2:14]([C:11]1[N:12]([CH3:13])[C:8]([C:6](=[O:7])[C:5]2[CH:21]=[CH:22][C:23]([O:24][CH3:25])=[C:3]([O:2][CH3:1])[CH:4]=2)=[C:9]([CH3:20])[CH:10]=1)[CH3:15].[CH2:11]([CH2:14][C:15]([O-:17])=[O:16])[CH2:10][CH3:9]

Participants

Reactant 2

HCID 336431-Iodopropane

HCID 18424209HCID 18424209, compound

Product 1

HCID 86584045HCID 86584045, compound

Procedure

The alkylation procedure of Example 77A is performed upon ethyl 5-(3′,4′-dimethoxybenzoyl)-1,4-dimethylpyrrole-2-acetate (from Example 90), using an equivalent quantity of n-propyl iodide instead of methyl iodide used in Example 77A to yield ethyl 5-(3′,4′-dimethoxybenzoyl)-1,4-dimethylpyrrole-2-(α-n-propyl)-acetate.

Sources & evidence

ORD record: ord-7bca7b9d1e3c4eb6a7b30cc10b317a2c
Source dataset: uspto-grants-2002_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06455703B2

Reaction notes

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