1-Iodopropane → HCID 86754409, compound

HRID 1282382Notes

Reaction equation

[CH3:1][C:2]1[CH:22]=[CH:21][CH:20]=[CH:19][C:3]=1[C:4]([C:6]1[N:10]([CH3:11])[C:9]([CH2:12][C:13]([O:15]CC)=[O:14])=[CH:8][C:7]=1[CH3:18])=[O:5].C(I)CC>>[CH2:12]([C:9]1[N:10]([CH3:11])[C:6]([C:4](=[O:5])[C:3]2[CH:19]=[CH:20][CH:21]=[CH:22][C:2]=2[CH3:1])=[C:7]([CH3:18])[CH:8]=1)[CH3:13].[CH2:9]([CH2:12][C:13]([O-:15])=[O:14])[CH2:8][CH3:7]

Participants

Reactant 2

HCID 336431-Iodopropane

HCID 18424360HCID 18424360, compound

Product 1

HCID 86754409HCID 86754409, compound

Procedure

The alkylation procedure of Example 77A is performed upon ethyl 5-(o-methylbenzoyl)-1,4-dimethylpyrrole-2-acetate (from Example 92), using an equivalent quantity of n-propyl iodide instead of methyl iodide used in Example 77A to yield ethyl 5-(o-methylbenzoyl)-1,4-dimethylpyrrole-2-(α-n-propyl)-acetate.

Sources & evidence

ORD record: ord-1604864cd81847c19400803f93504ec9
Source dataset: uspto-grants-2002_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06455703B2

Reaction notes

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