反应详情

A mixture of 4-(2-chloro-5-trifluoromethylphenyl)-1-fluoro-2-fluoromethyl-3-butyn-2-ol (44.5 g), 5% palladium-barium carbonate (6.6 g), pyridine (2.3 g) and ethyl acetate (500 ml) was stirred under a hydrogen atmosphere at room temperature for 10 days. The catalyst was filtered off from the reaction mixture; subsequent concentrating under reduced pressure gave 4-(2-chloro-5-trifluoromethylphenyl)-1-fluoro-2-fluoromethyl-3-cis-buten-2-ol (44.0 g).

1. filtrationThe catalyst was filtered off from the reaction mixture
2. concentrationsubsequent concentrating under reduced pressure