HCID 18424406, compound → HCID 18424397, compound

HRID 1282428Notes

Reaction equation

HRID 1282428 reaction equation
[F:1][CH2:2][C:3]([CH2:23][F:24])([O:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][CH:14]=1)[C:4]#[C:5][C:6]([NH:8][CH2:9][CH2:10][CH3:11])=[O:7]>ClC1C=CC=CC=1Cl>[F:1][CH2:2][C:3]1([CH2:23][F:24])[CH:4]=[C:5]([C:6]([NH:8][CH2:9][CH2:10][CH3:11])=[O:7])[C:18]2[CH:17]=[C:16]([C:19]([F:20])([F:21])[F:22])[CH:15]=[CH:14][C:13]=2[O:12]1

Participants

3

Reactant 1

HCID 18424406HCID 18424406, compound

Product 1

HCID 18424397HCID 18424397, compoundYield 62%

Reagents, catalysts & solvents 1

HCID 72391,2-DichlorobenzeneSolvent

Procedure

An amount (50 mg) of 5-fluoro-4-fluoromethyl-4-(4-trifluoromethylphenoxy)-N-propyl-2-pentynamide was dissolved in o-dichlorobenzene (5 ml) and the solution was heated under reflux for 3.5 hours. The reaction mixture was concentrated under reduced pressure and the resulting residue was subjected to silica gel column chromatography (eluent; hexane/ethyl acetate=3/1) to give the titled compound (31 mg).

Workup

  1. temperaturethe solution was heated
  2. temperatureunder reflux for 3.5 hours
  3. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-d6650db3b3504da481e1e47006483c3b
Source dataset
uspto-grants-2002_09
Patent number
US06455708B1

Reaction notes

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