反应详情

1 cis/trans 2-(2,2-dichlorovinyl)-3,3-dimethylcyclopropane carboxylic acid (2.3 g), 2-bromo-6-chlorobenzylbromide (2.85 g) and potassium carbonate (1.6 g) were stirred together in acetone (30 ml) under reflux for 6 hours. The reaction mixture was cooled, diluted with water, and extracted three times with 50 ml portions of diethyl ether. The combined ether extracts were washed with water and with aqueous sodium bicarbonate solution (three times), dried over magnesium sulphate and evaporated to give the orange title product (4. g, 98%) m.p. 61°-67° C.

1. temperatureunder reflux for 6 hours
2. temperatureThe reaction mixture was cooled
3. extractionextracted three times with 50 ml portions of diethyl ether
4. washThe combined ether extracts were washed with water and with aqueous sodium bicarbonate solution (three times)
5. dry with materialdried over magnesium sulphate
6. customevaporated