HCID 23385756, compound → HCID 23385753, compound

HRID 1282502Notes

Reaction equation

HRID 1282502 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10]([NH:13][CH2:14][CH2:15][CH2:16][C@@H:17]([C:36]([OH:38])=[O:37])[NH:18][C:19]([O:21][CH2:22][CH:23]2[C:35]3[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=3[C:29]3[C:24]2=[CH:25][CH:26]=[CH:27][CH:28]=3)=[O:20])(=[O:12])=[O:11])=[CH:6][CH:5]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([S:10]([NH:13][CH2:14][CH2:15][CH2:16][C@@H:17]([C:36]([OH:38])=[O:37])[NH:18][C:19]([O:21][CH2:22][CH:23]2[C:35]3[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=3[C:29]3[C:24]2=[CH:25][CH:26]=[CH:27][CH:28]=3)=[O:20])(=[O:11])=[O:12])=[CH:8][CH:9]=1

Participants

4

Reactant 1

HCID 23385756HCID 23385756, compound

Product 1

HCID 23385753HCID 23385753, compoundYield 96%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The product obtained from example 28 (54.0 mg, 0.10 mmol) was dissolved in MeOH (5 mL) and then hydrogenated using 10% Pd/C as catalyst at atmospheric pressure for 1 h. The catalyst was filtered off and the filtrate was evaporated in vacuo to yield 96% of the title compound.

Workup

  1. customfor 1 h
  2. filtrationThe catalyst was filtered off
  3. customthe filtrate was evaporated in vacuo

Sources & evidence

ORD record
ord-cf4cea4e534d4f69aa7d6eba5b46384d
Source dataset
uspto-grants-2002_09
Patent number
US06455587B1

Reaction notes

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