2,3-Dimethoxycinnamic acid → HCID 10122653, compound

HRID 1282535Notes

Reaction equation

HRID 1282535 reaction equation
[CH2:1]([N:5]([S:15]([C:18]1[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][CH:19]=1)(=[O:17])=[O:16])[C@H:6]([C:12]([OH:14])=[O:13])[CH2:7][CH2:8][CH2:9][CH2:10][NH2:11])[CH:2]([CH3:4])[CH3:3].[CH3:25][O:26][C:27]1[C:37]([O:38][CH3:39])=[CH:36][CH:35]=[CH:34][C:28]=1[CH:29]=[CH:30][C:31](O)=[O:32]>>[CH2:1]([N:5]([S:15]([C:18]1[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][CH:19]=1)(=[O:17])=[O:16])[C@H:6]([C:12]([OH:14])=[O:13])[CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:31](=[O:32])[CH2:30][CH2:29][C:28]1[CH:34]=[CH:35][CH:36]=[C:37]([O:38][CH3:39])[C:27]=1[O:26][CH3:25])[CH:2]([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 995252,3-Dimethoxycinnamic acidHCID 23552860Nalpha-isobutyl-Nalpha-(4-methylbenzenesulfonyl)-L-lysine

Product 1

HCID 10122653HCID 10122653, compoundYield 18%

Procedure

Nα-isobutyl-Nα-(4-methylbenzenesulfonyl)-L-lysine was reacted with 2,3-dimethoxycinnamic acid under the conditions described in example 86. The crude material was purified by flash chromatography (CH2Cl2:MeOH, 49:1 to 9:1) to yield 18% of the desired product.

Workup

  1. customThe crude material was purified by flash chromatography (CH2Cl2:MeOH, 49:1 to 9:1)

Sources & evidence

ORD record
ord-07a7fc3721ae40749e925033d47f64d9
Source dataset
uspto-grants-2002_09
Patent number
US06455587B1

Reaction notes

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