Phenoxyacetyl chloride → HCID 513410, compound

HRID 1282536Notes

Reaction equation

HRID 1282536 reaction equation
[CH2:1]([N:5]([S:15]([C:18]1[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][CH:19]=1)(=[O:17])=[O:16])[C@H:6]([C:12]([OH:14])=[O:13])[CH2:7][CH2:8][CH2:9][CH2:10][NH2:11])[CH:2]([CH3:4])[CH3:3].[O:25]([CH2:32][C:33](Cl)=[O:34])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[CH2:1]([N:5]([S:15]([C:18]1[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][CH:19]=1)(=[O:17])=[O:16])[C@H:6]([C:12]([OH:14])=[O:13])[CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:33](=[O:34])[CH2:32][O:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[CH:2]([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 69703Phenoxyacetyl chlorideHCID 23552860Nalpha-isobutyl-Nalpha-(4-methylbenzenesulfonyl)-L-lysine

Product 1

HCID 513410HCID 513410, compoundYield 77%

Procedure

Nα-isobutyl-Nα-(4-methylbenzenesulfonyl)-L-lysine was reacted with phenoxyacetyl chloride under the conditions described in example 2. The crude material was purified by flash chromatography (CH2Cl2:MeOH, 19:1 to 9:1) to yield 77% of the desired product.

Workup

  1. customThe crude material was purified by flash chromatography (CH2Cl2:MeOH, 19:1 to 9:1)

Sources & evidence

ORD record
ord-969753b406a44e3b859cfb64cf5bf976
Source dataset
uspto-grants-2002_09
Patent number
US06455587B1

Reaction notes

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