2-Amino-6-methylpyridine → 4-Hydroxy-2-methyl-N-(6-methyl-2-pyridyl)-2H-[1]benzothieno-[2,3-e]-1,2-thiazine-3-carboxamide-1,1-dioxide

HRID 128260Notes

Reaction equation

HRID 128260 reaction equation
[OH:1][C:2]1[C:7]2[S:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[C:6]=2[S:5](=[O:16])(=[O:15])[N:4]([CH3:17])[C:3]=1[C:18](OC)=[O:19].[NH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([CH3:29])[N:24]=1>>[OH:1][C:2]1[C:7]2[S:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[C:6]=2[S:5](=[O:16])(=[O:15])[N:4]([CH3:17])[C:3]=1[C:18]([NH:22][C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([CH3:29])[N:24]=1)=[O:19]

Participants

3

Reactant 2

HCID 157652-Amino-6-methylpyridineHCID 547072593-carbomethoxy-4-hydroxy-2-methyl-2H-[1]benzothieno[2,3-e]-1,2-thiazine 1,1-dioxide

Product 1

HCID 705468154-Hydroxy-2-methyl-N-(6-methyl-2-pyridyl)-2H-[1]benzothieno-[2,3-e]-1,2-thiazine-3-carboxamide-1,1-dioxideYield 33%

Procedure

Prepared analogous to Example 1 from methyl 4-hydroxy-2-methyl-2H-[1]-benzothieno[2,3-e]-1,2-thiazine-3-carboxylate-1,1-dioxide and 2-amino-6-methyl-pyridine with a yield of 33% of theory.

Sources & evidence

ORD record
ord-d614230b31604881907938e3fccd5ead
Source dataset
uspto-grants-1981_03
Patent number
US04259336

Reaction notes

Loading…