2-Amino-4-methylthiazole → 2H-(1)Benzothieno(2,3-e)-1,2-thiazine-3-carboxamide, 4-hydroxy-2-methyl-N-(4-methyl-2-thiazolyl)-, 1,1-dioxide

HRID 128261Notes

Reaction equation

HRID 128261 reaction equation
[OH:1][C:2]1[C:7]2[S:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[C:6]=2[S:5](=[O:16])(=[O:15])[N:4]([CH3:17])[C:3]=1[C:18](OC)=[O:19].[NH2:22][C:23]1[S:24][CH:25]=[C:26]([CH3:28])[N:27]=1>>[OH:1][C:2]1[C:7]2[S:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[C:6]=2[S:5](=[O:16])(=[O:15])[N:4]([CH3:17])[C:3]=1[C:18]([NH:22][C:23]1[S:24][CH:25]=[C:26]([CH3:28])[N:27]=1)=[O:19]

Participants

3

Reactant 2

HCID 741432-Amino-4-methylthiazoleHCID 547072593-carbomethoxy-4-hydroxy-2-methyl-2H-[1]benzothieno[2,3-e]-1,2-thiazine 1,1-dioxide

Product 1

HCID 546976402H-(1)Benzothieno(2,3-e)-1,2-thiazine-3-carboxamide, 4-hydroxy-2-methyl-N-(4-methyl-2-thiazolyl)-, 1,1-dioxideYield 66%

Procedure

Prepared analogous to Example 1 from methyl 4-hydroxy-2-methyl-2H-[1]benzothieno[2,3-e]-1,2-thiazine-3-carboxylate-1,1-dioxide and 2-amino-4-methyl-thiazole with a yield of 66% of theory.

Sources & evidence

ORD record
ord-e70dc1d9ec6742b6905a14ebb6b350e0
Source dataset
uspto-grants-1981_03
Patent number
US04259336

Reaction notes

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