Phosphorus pentachloride → HCID 86732977, compound

HRID 1282713Notes

Reaction equation

HRID 1282713 reaction equation
[ClH:1].[O:2]=[C:3]([CH2:5][N:6]([C:8](=[NH:10])[NH2:9])[CH3:7])O.P(Cl)(Cl)(Cl)(Cl)[Cl:12]>C(Cl)Cl>[ClH:12].[CH3:7][N:6]([CH2:5][C:3]([Cl:1])=[O:2])[C:8]([NH2:9])=[NH:10]

Participants

4

Reactant 2

HCID 24819Phosphorus pentachlorideHCID 134732N-Carbamimidoyl-N-methylglycine--hydrogen chloride (1/1)

Product 1

HCID 86732977HCID 86732977, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Creatine hydrochloride (1.85 g., 0.01 mole) in methylene chloride (50 ml.) was treated with phosphorous pentachloride (2.06 g., 0.01 mole) at room temperature. The mixture was stirred overnight at room temperature and the acid chloride product filtered off, washed with methylene chloride and dried.

Workup

  1. filtrationthe acid chloride product filtered off
  2. washwashed with methylene chloride
  3. customdried

Sources & evidence

ORD record
ord-1fd4e25b6bdf4e658c06c86982933545
Source dataset
uspto-grants-1976_08
Patent number
US03972872

Reaction notes

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