2-Aminopyridine → HCID 20158103, compound

HRID 1282723Notes

Reaction equation

HRID 1282723 reaction equation
[CH3:1][C:2]1[C:7]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[C:6]([CH3:15])[O:5][C:4](=O)[CH:3]=1.NC1C=CC=CN=1.Cl.[NH2:25][OH:26]>>[OH:26][N:25]1[C:6]([CH3:15])=[C:7]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:2]([CH3:1])=[CH:3][C:4]1=[O:5]

Participants

4

Reactant 3

HCID 104392-AminopyridineHCID 443297Hydroxyamine hydrochlorideHCID 21520127HCID 21520127, compound

Product 1

HCID 20158103HCID 20158103, compoundYield 41.6%

Procedure

2 g of 4,6-dimethyl-5-benzyl-2-pyrone, 4 g of 2-aminopyridine and 0.9 g of hydroxylamine hydrochloride were heated for 5 hours to 80° C. After the usual working up, there were obtained 0.89 g (42 %) of 1-hydroxy-4,6-dimethyl-5-benzyl-2-pyridone melting at 165° C (Calc.: 6.1 % N, found: 6.1 % N).

Sources & evidence

ORD record
ord-873021cc8d7b4bd09b047c31b6fb70e8
Source dataset
uspto-grants-1976_08
Patent number
US03972888

Reaction notes

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