2-Aminopyridine → HCID 18407406, compound

HRID 1282724Notes

Reaction equation

HRID 1282724 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([CH3:14])=[CH:10][CH:9]=2)[O:5][C:4](=O)[CH:3]=1.Cl.[NH2:17][OH:18].NC1C=CC=CN=1>>[OH:18][N:17]1[C:6]([C:8]2[CH:13]=[CH:12][C:11]([CH3:14])=[CH:10][CH:9]=2)=[CH:7][C:2]([CH3:1])=[CH:3][C:4]1=[O:5]

Participants

4

Reactant 3

HCID 104392-AminopyridineHCID 443297Hydroxyamine hydrochlorideHCID 21520151HCID 21520151, compound

Product 1

HCID 18407406HCID 18407406, compoundYield 16.1%

Procedure

1 g of 4-methyl-6-(4-tolyl)-2-pyrone, 0.6 g of hydroxylamine hydrochloride and 4 g of 2-aminopyridine were heated for 1 hour to 80° C. After the usual working up, 0.173 g (16.1 %) of 1-hydroxy-4-methyl-6-(4-tolyl)-2-pyridone melting at 125° C (calc.: 6.5 % N, found: 6,6 % N) were isolated. When using pyridine instead of aminopyridine under otherwise equal reaction conditions, the yield was 0.012 g (1.1 %) only.

Sources & evidence

ORD record
ord-3aee06233f4941aa8f90c482f011e687
Source dataset
uspto-grants-1976_08
Patent number
US03972888

Reaction notes

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