2-Aminopyridine → HCID 20158062, compound

HRID 1282726Notes

Reaction equation

HRID 1282726 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH2:8][C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)[O:5][C:4](=O)[CH:3]=1.Cl.[NH2:18][OH:19].NC1C=CC=CN=1>>[OH:19][N:18]1[C:6]([CH2:8][C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)=[CH:7][C:2]([CH3:1])=[CH:3][C:4]1=[O:5]

Participants

4

Reactant 3

HCID 104392-AminopyridineHCID 443297Hydroxyamine hydrochlorideHCID 21520132HCID 21520132, compound

Product 1

HCID 20158062HCID 20158062, compoundYield 62%

Procedure

5 g of 4-methyl-6-(4-chlorobenzyl)-2-pyrone, 2.5 g of hydroxylamine hydrochloride and 10 g of 2-aminopyridine were heated for 16 hours to 60°C. After the usual working up, there were obtained 3.3 g (62 %) of 1-hyroxy-4-methyl-6-(4-chlorobenzyl)-2-pyridone melting at 142° C (Calc.: 5.6% N, found 5.9 % N).

Sources & evidence

ORD record
ord-eab90cd0a9754432a2e0394d9fa50de8
Source dataset
uspto-grants-1976_08
Patent number
US03972888

Reaction notes

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