Aminopyrazine → 4-Hydroxy-2-methyl-N-(pyrazinyl)-2H-[1] benzothieno [2,3-e]-1,2-thiazine-3-carboxamide-1,1-dioxide

HRID 128278Notes

Reaction equation

[OH:1][C:2]1[C:7]2[S:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[C:6]=2[S:5](=[O:16])(=[O:15])[N:4]([CH3:17])[C:3]=1[C:18](OCC)=[O:19].[NH2:23][C:24]1[CH:29]=[N:28][CH:27]=[CH:26][N:25]=1>>[OH:1][C:2]1[C:7]2[S:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[C:6]=2[S:5](=[O:15])(=[O:16])[N:4]([CH3:17])[C:3]=1[C:18]([NH:23][C:24]1[CH:29]=[N:28][CH:27]=[CH:26][N:25]=1)=[O:19]

Participants

Reactant 2

HCID 78747Aminopyrazine

HCID 70577588ethyl 4-hydroxy-2-methyl-2H-[1]-benzothieno[2,3-e]-1,2-thiazine-3-carboxylate-1,1-dioxide

Product 1

HCID 867376434-Hydroxy-2-methyl-N-(pyrazinyl)-2H-[1] benzothieno [2,3-e]-1,2-thiazine-3-carboxamide-1,1-dioxideYield 52%

Procedure

Prepared analogous to Example 1 from ethyl 4-hydroxy-2-methyl-2H-[1] benzothieno [2,3-e]-1,2-thiazine-3-carboxylate-1,1-dioxide and aminopyrazine with a yield of 52% of theory.

Sources & evidence

ORD record: ord-58fd7da5ae444dfa9299f3fa3749aa51
Source dataset: uspto-grants-1981_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04259336

Reaction notes

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