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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 128278Generated: October 31, 2026

Aminopyrazine → 4-Hydroxy-2-methyl-N-(pyrazinyl)-2H-[1] benzothieno [2,3-e]-1,2-thiazine-3-carboxamide-1,1-dioxide

https://huagongshe.com/reaction/128278

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAminopyrazineHCID 78747—
Reactantethyl 4-hydroxy-2-methyl-2H-[1]-benzothieno[2,3-e]-1,2-thiazine-3-carboxylate-1,1-dioxideHCID 70577588—
Product4-Hydroxy-2-methyl-N-(pyrazinyl)-2H-[1] benzothieno [2,3-e]-1,2-thiazine-3-carboxamide-1,1-dioxideHCID 8673764352%

Reaction Steps

Prepared analogous to Example 1 from ethyl 4-hydroxy-2-methyl-2H-[1] benzothieno [2,3-e]-1,2-thiazine-3-carboxylate-1,1-dioxide and aminopyrazine with a yield of 52% of theory.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04259336
Source datasetuspto-grants-1981_03
ORD IDord-58fd7da5ae444dfa9299f3fa3749aa51
Source noteuspto-grants-1981_03