反应详情

温度

55 °C

A mixture of 5-amino-3-mercapto-4-phenoxybenzoic acid (2.6 g), sodium hydrogen carbonate (2g), saturated sodium hydrogen carbonate (100 ml), and sec-butyl iodide (2.2 g) is stirred for 6 hours at 55°C. After cooling, 5-amino-3-sec-butylthio-4-phenoxybenzoic acid is precipitated by adition of hydrochloric acid until pH 2.5. After collection, recrystallization from aqueous ethanol, and drying in vacuo at 80°C, the compound is obtained with a melting point of 157°-158°C.

1. temperatureAfter cooling
2. custom5-amino-3-sec-butylthio-4-phenoxybenzoic acid is precipitated by adition of hydrochloric acid until pH 2.5
3. customAfter collection, recrystallization from aqueous ethanol
4. customdrying in vacuo at 80°C
5. customthe compound is obtained with a melting point of 157°-158°C.