反应详情

A mixture of 3-n-butylthio-4-phenoxy-5-sulfamylbenzoic acid (2.5 g) and methanol (75 ml) is saturated with gaseous hydrogen chloride. The reaction mixture is allowed to warm during saturation. After cooling and standing for 5 hours, the reaction mixture is evaporated in vacuo. The residue is triturated with water and sufficient sodium hydrogen carbonate to neutralize traces of hydrochloric acid. The precipitated methyl 3-n-butylthio-4-phenoxy-5-sulfamylbenzoate is collected and recrystallized from methanol/water to yield the ester with a melting point of 122°-123°C.

1. temperatureto warm during saturation
2. temperatureAfter cooling
3. customthe reaction mixture is evaporated in vacuo
4. customThe residue is triturated with water and sufficient sodium hydrogen carbonate
5. customThe precipitated methyl 3-n-butylthio-4-phenoxy-5-sulfamylbenzoate is collected
6. customrecrystallized from methanol/water