反应详情

温度

60 °C

10.5 g. (0.05 mole) of ethyl 4-bromo-2-methylbutyrate was combined with 17.0 g. (0.20 mole) of piperidine and 100 ml. of benzene and stirred for 16 hours at room temperature and then heated at 60°C. for 4 hours. The reaction mixture was cooled and the colorless solid which appeared was removed by filtration. The mother liquor was concentrated to give a mobile yellow liquid which distilled (b.p. 78°C. at 0.25 mm) as 6.7 g. (63%) of colorless liquid.

1. temperatureThe reaction mixture was cooled
2. customthe colorless solid which appeared was removed by filtration
3. concentrationThe mother liquor was concentrated
4. customto give a mobile yellow liquid which
5. distillationdistilled (b.p. 78°C. at 0.25 mm) as 6.7 g