HRID1282861

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10868

Dicyclohexylcarbodiimide

C13H22N2

HCID21152689

未命名化合物

结构：CCCCCC(C)C(C)c1cc(O)c2c(c1)OC(C)(C)C1=C2C(C)CCS1

HCID21519993

未命名化合物

PRODUCTS

生成物

结构：CCCCCC(C)C(C)c1cc(OC(=O)C(C)CCN2CCCCC2)c2c(c1)OC(C)(C)C1=C2C(C)CCS1.Cl

HCID68132198

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

1,2-dihydro-10-hydroxy-8-(3-methyl-2-octyl)-1,5,5-trimethyl-3H,5H-thiopyrano[2,3-c][1]benzopyran is reacted with 2-methyl-4-piperidinobutyric acid hydrochloride in methylene chloride in the presence of dicyclohexylcarbodiimide, according to the procedure of Example 28, to produce the desired ester.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c90d5d1cb408408f9c215597224edb30
来源数据集: uspto-grants-1976_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US03972880
来源说明: uspto-grants-1976_08

反应 SMILES

[OH:1][C:2]1[C:7]2[C:8]3[CH:17]([CH3:18])[CH2:16][CH2:15][S:14][C:9]=3[C:10]([CH3:13])([CH3:12])[O:11][C:6]=2[CH:5]=[C:4]([CH:19]([CH:21]([CH3:27])[CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[CH3:20])[CH:3]=1.[ClH:28].[CH3:29][CH:30]([CH2:34][CH2:35][N:36]1[CH2:41][CH2:40][CH2:39][CH2:38][CH2:37]1)[C:31](O)=[O:32].C1(N=C=NC2CCCCC2)CCCCC1>C(Cl)Cl>[ClH:28].[CH3:27][CH:21]([CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[CH:19]([C:4]1[CH:3]=[C:2]([O:1][C:31](=[O:32])[CH:30]([CH3:29])[CH2:34][CH2:35][N:36]2[CH2:41][CH2:40][CH2:39][CH2:38][CH2:37]2)[C:7]2[C:8]3[CH:17]([CH3:18])[CH2:16][CH2:15][S:14][C:9]=3[C:10]([CH3:13])([CH3:12])[O:11][C:6]=2[CH:5]=1)[CH3:20]