Thionyl Chloride → N-(Trifluoroacetyl)-L-valyl chloride

HRID 1282869Notes

Reaction equation

[F:1][C:2]([F:14])([F:13])[C:3]([NH:5][C@H:6]([C:10](O)=[O:11])[CH:7]([CH3:9])[CH3:8])=[O:4].S(Cl)([Cl:17])=O>>[F:1][C:2]([F:14])([F:13])[C:3]([NH:5][C@H:6]([C:10]([Cl:17])=[O:11])[CH:7]([CH3:9])[CH3:8])=[O:4]

Participants

Reactant 2

HCID 24386Thionyl Chloride

HCID 2755241349-00-8

Product 1

HCID 54035397N-(Trifluoroacetyl)-L-valyl chloride

Procedure

A solution of 1 g. of N-trifluoroacetyl-L-valine in 5 ml. of thionyl chloride was cooled to 5°C. and stirred for 15 minutes. The excess thionyl chloride was removed under reduced pressure under a stream of dry nitrogen gas, affording N-trifluoroacetyl-L-valyl chloride as an oil.

Workup

customThe excess thionyl chloride was removed under reduced pressure under a stream of dry nitrogen gas

Sources & evidence

ORD record: ord-420b3c353f034e65996b1f623409410b
Source dataset: uspto-grants-1976_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03972925

Reaction notes

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