Formaldehyde → HCID 13706886, compound

After addition of dimethyl malonate (0.50 mole) to a solution of sodium methylate (0.50 mole in 400 ml methanol), octadecyl bromide (0.45 mole) is added dropwise. The reaction mixture was heated gently during the addition and the mixture was refluxed for 10 hours after addition of the halide. At the end of this time, the methanol was distilled off. The residue was cooled and stirred with 500 ml of water. The product, a pasty solid, floated on top of the water, and ether (350 mole) was added to dissolve it. The ether layer was evaporated, and the product was recrystallized from 900 ml of methanol. After recrystallization from methanol and drying in a vacuum oven, a 69.2 percent yield was obtained, m.p. 45°-47° C. The dimethyl-n-octadecylmalonate (0.17 mole), dissolved in 200 ml of methanol, was added to a solution of 11.3g potassium hydroxide (86.1 percent) in 45 ml of methanol. The mixture was stirred for 1.5 days and the potassium salt which separated was filtered. The salt was dissolved in 500 ml of water with stirring. After acidifying with 6N HCl, the solution was stirred for 3 hours to flocculate the precipitate. The product was filtered, washed and dried in a vacuum oven. A 95 percent yield was obtained, m.p. 68°-70° C. Methyl hydrogen octadecylmalonate (0.16 mole), diethyl amine (0.16 mole), and 13g of a 37 percent formaldehyde solution were stirred with heating to initiate the reaction, after which stirring was continued without heating for 6 hours. After standing overnight, impure solid acrylate had settled out. The pasty product layer was washed with hydrochloric acid followed by water until neutral (sodium sulfate was used to break emulsions formed during the washing). The ether layer was dried over anhydrous potassium carbonate. The solution was filtered and evaporated. The compound was crystallized from benzene. A 40 percent yield was obtained, m.p. 48°-50°C.

1. additionis added dropwise
2. temperatureThe reaction mixture was heated gently during the addition
3. temperaturethe mixture was refluxed for 10 hours
4. distillationAt the end of this time, the methanol was distilled off
5. temperatureThe residue was cooled
6. additionwas added
7. dissolutionto dissolve it
8. customThe ether layer was evaporated
9. customthe product was recrystallized from 900 ml of methanol
10. customAfter recrystallization from methanol
11. customdrying in a vacuum oven
12. customa 69.2 percent yield was obtained
13. stirringThe mixture was stirred for 1.5 days
14. customthe potassium salt which separated
15. filtrationwas filtered
16. dissolutionThe salt was dissolved in 500 ml of water
17. stirringwith stirring
18. stirringthe solution was stirred for 3 hours
19. filtrationThe product was filtered
20. washwashed
21. customdried in a vacuum oven
22. customA 95 percent yield was obtained
23. temperaturewith heating
24. customthe reaction
25. stirringafter which stirring
26. temperaturewithout heating for 6 hours
27. washThe pasty product layer was washed with hydrochloric acid
28. customformed during the washing)
29. dry with materialThe ether layer was dried over anhydrous potassium carbonate
30. filtrationThe solution was filtered
31. customevaporated
32. customThe compound was crystallized from benzene
33. customA 40 percent yield was obtained

ORD record

ord-21049af0592343df8b4609711244f32b

Source dataset

uspto-grants-1976_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US03972864