Sodium Hydroxide → HCID 54012521, compound

HRID 1282908Notes

Reaction equation

HRID 1282908 reaction equation
[CH2:1]([N:3]1[CH2:10][CH:9]2[CH:5]([CH2:6][CH2:7][CH2:8]2)[CH:4]1[CH2:11][NH:12][C:13](=[O:27])[C:14]1[CH:19]=[C:18]([Cl:20])[C:17]([NH:21]C(=O)C)=[CH:16][C:15]=1[O:25][CH3:26])[CH3:2].[OH-].[Na+]>C(O)C>[CH2:1]([N:3]1[CH2:10][CH:9]2[CH:5]([CH2:6][CH2:7][CH2:8]2)[CH:4]1[CH2:11][NH:12][C:13](=[O:27])[C:14]1[CH:19]=[C:18]([Cl:20])[C:17]([NH2:21])=[CH:16][C:15]=1[O:25][CH3:26])[CH3:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86733791Benzamide, 4-(acetylamino)-5-chloro-N-[(2-ethyloctahydrocyclopenta[c]pyrrol-1-yl)methyl]-2-methoxy-

Product 1

HCID 54012521HCID 54012521, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

7 parts of N-ethyl-2-(2-methoxy-4-acetylamino-5-chloro benzamido methyl)-3-azabicyclo (3,3,0) octane were heated for 30 minutes in the presence of 17.7 parts of a 2 N solution of sodium hydroxide and 15 parts of ethanol. After cooling, the precipitate was filtered and recrystallized in 40 parts of acetonitrile. There were obtained 5 parts of N-ethyl-2-(2-methoxy-4-amino-5-chloro benzamido methyl)-3-azabicyclo(3,3,0) octane, M.P. 128°-129° C.

Workup

  1. temperatureAfter cooling
  2. filtrationthe precipitate was filtered
  3. customrecrystallized in 40 parts of acetonitrile

Sources & evidence

ORD record
ord-ca0c83e39c3b47b58913784c09c36cd8
Source dataset
uspto-grants-1976_08
Patent number
US03972994

Reaction notes

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