HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 54012521, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Benzamide, 4-(acetylamino)-5-chloro-N-[(2-ethyloctahydrocyclopenta[c]pyrrol-1-yl)methyl]-2-methoxy- | HCID 86733791 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 54012521 | HCID 54012521 | — |
Reaction Steps
7 parts of N-ethyl-2-(2-methoxy-4-acetylamino-5-chloro benzamido methyl)-3-azabicyclo (3,3,0) octane were heated for 30 minutes in the presence of 17.7 parts of a 2 N solution of sodium hydroxide and 15 parts of ethanol. After cooling, the precipitate was filtered and recrystallized in 40 parts of acetonitrile. There were obtained 5 parts of N-ethyl-2-(2-methoxy-4-amino-5-chloro benzamido methyl)-3-azabicyclo(3,3,0) octane, M.P. 128°-129° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03972994 |
| Source dataset | uspto-grants-1976_08 |
| ORD ID | ord-ca0c83e39c3b47b58913784c09c36cd8 |
| Source note | uspto-grants-1976_08 |