2-Aminothiazole → HCID 54702568, compound

HRID 128291Notes

Reaction equation

HRID 128291 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]2[C:8]3[S:13](=[O:15])(=[O:14])[N:12]([CH3:16])[C:11]([C:17](OC)=[O:18])=[C:10]([OH:21])[C:9]=3[S:22][C:4]=2[CH:3]=1.[NH2:23][C:24]1[S:25][CH:26]=[CH:27][N:28]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]2[C:8]3[S:13](=[O:14])(=[O:15])[N:12]([CH3:16])[C:11]([C:17]([NH:23][C:24]4[S:25][CH:26]=[CH:27][N:28]=4)=[O:18])=[C:10]([OH:21])[C:9]=3[S:22][C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 21552-AminothiazoleHCID 70579947HCID 70579947, compound

Product 1

HCID 54702568HCID 54702568, compoundYield 56%

Procedure

Prepared analogous to Example 1 from methyl 7-chloro-4-hydroxy-2-methyl-2H-[1] benzothieno [2,3-e]-1,2-thiazine-3-carboxylate-1,1-dioxide and 2-aminothiazole with a yield of 56% of theory.

Sources & evidence

ORD record
ord-55de7409782947869fc7aeab176906f4
Source dataset
uspto-grants-1981_03
Patent number
US04259336

Reaction notes

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