Diclofenac → HCID 21520578, compound

HRID 1282915Notes

Reaction equation

HRID 1282915 reaction equation
[Cl:1][C:2]1[CH:18]=[CH:17][CH:16]=[C:15]([Cl:19])[C:3]=1[NH:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH2:11][C:12]([OH:14])=[O:13].[CH2:20](OC(OCC(C)(C)C)N(C)C)[C:21](C)(C)[CH3:22].OCC[C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][N:40]=1>>[N:40]1[CH:39]=[CH:44][C:43]([CH2:20][CH2:21][CH2:22][O:13][C:12](=[O:14])[CH2:11][C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[NH:4][C:3]2[C:2]([Cl:1])=[CH:18][CH:17]=[CH:16][C:15]=2[Cl:19])=[CH:42][CH:41]=1

Participants

4

Reactant 3

HCID 3033DiclofenacHCID 76752-(2-Hydroxyethyl)pyridineHCID 786231,1-Bis(2,2-dimethylpropoxy)-N,N-dimethylmethanamine

Product 1

HCID 21520578HCID 21520578, compound

Procedure

In analogous manner [o-(2,6-dichloro-anilino)-phenyl]-acetic acid-2-(2-pyridyl)-ethyl ester with a melting point of 67°-68°C (crystallisation from petroleum ether) is obtained starting from 2.96 g of [o-(2,6-dichloro-anilino)-phenyl]-acetic acid, 3.0 g of dimethyl formamide-dineopentylacetal, and 1.4 g of 2-(2-hydroxyethyl)-pyridine.

Workup

  1. customIn analogous manner [o-(2,6-dichloro-anilino)-phenyl]-acetic acid-2-(2-pyridyl)-ethyl ester with a melting point of 67°-68°C (crystallisation from petroleum ether)
  2. customis obtained

Sources & evidence

ORD record
ord-9525f945ad5248f68ce6bd677aaf3826
Source dataset
uspto-grants-1976_08
Patent number
US03973024

Reaction notes

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