Hydrochloric Acid → HCID 68135538, compound

HRID 1282917Notes

Reaction equation

HRID 1282917 reaction equation
Cl.[N:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][O:11][C:12](=[O:29])[CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[NH:20][C:21]2[C:26]([Cl:27])=[CH:25][CH:24]=[CH:23][C:22]=2[Cl:28])=[CH:4][CH:3]=1>CCOCC>[ClH:27].[N:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][O:11][C:12](=[O:29])[CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[NH:20][C:21]2[C:22]([Cl:28])=[CH:23][CH:24]=[CH:25][C:26]=2[Cl:27])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21520578HCID 21520578, compound

Product 1

HCID 68135538HCID 68135538, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

While stirring, 10 ml of 2 normal ethereal hydrochloric acid are added dropwise to a solution of 4.2 g of [o-(2,6-dichloro-anilino)-phenyl]-acetic acid-3-(4-pyridyl)-propyl ester (cf. Example 3) in 100 ml of anhydrous ether. The precipitated crystals are filtered off and recrystallised from ethanol/ether. The [o-(2,6-dichloro-anilino)-phenyl]-acetic acid-3-(4-pyridyl)-propyl ester hydrochloride melts at 166°-170°C.

Workup

  1. filtrationThe precipitated crystals are filtered off
  2. customrecrystallised from ethanol/ether

Sources & evidence

ORD record
ord-d54eb491b5e34d0db41b49458d05b98c
Source dataset
uspto-grants-1976_08
Patent number
US03973024

Reaction notes

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