Sodium Hydroxide → HCID 53735981, compound

HRID 1282951Notes

Reaction equation

HRID 1282951 reaction equation
[OH-].[Na+].CO[C:5](=O)[C:6]([C:24]#[N:25])(C)[C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]=[C:12]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH:11]=[CH:10]2>C(O)C>[CH3:5][CH:6]([C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]=[C:12]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH:11]=[CH:10]2)[C:24]#[N:25]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 54270893HCID 54270893, compound

Product 1

HCID 53735981HCID 53735981, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

36.4 ml of 1 N sodium hydroxide solution are added dropwise to a solution of 10.4 g of α-cyano-α-methyl-2-phenyl-6-quinolineacetic acid methyl ester in 580 ml of ethanol at room temperature. The reaction mixture is stirred for 16 hours at room temperature and evaporated to dryness, the residue is treated with water and the suspension thereby produced is filtered off. After drying in vacuo at 40°C, crude α-methyl-2-phenyl-6-quinolineacetonitrile is obtained, which is directly processed further.

Workup

  1. customevaporated to dryness
  2. additionthe residue is treated with water
  3. customthe suspension thereby produced
  4. filtrationis filtered off
  5. customAfter drying in vacuo at 40°C

Sources & evidence

ORD record
ord-b5e8ec7d530b487b94680f6ef3d33e9d
Source dataset
uspto-grants-1976_08
Patent number
US03973022

Reaction notes

Loading…