Acetyl chloride → HCID 21518736, compound

HRID 1282973Notes

Reaction equation

HRID 1282973 reaction equation
[CH:1]([N:4]1[C:9](=[O:10])[N:8]=[C:7]([S:11][CH3:12])[NH:6][C:5]1=[O:13])([CH3:3])[CH3:2].[Na].[C:15](Cl)(=[O:17])[CH3:16]>O1CCCC1>[C:15]([N:8]1[C:7]([S:11][CH3:12])=[N:6][C:5](=[O:13])[N:4]([CH:1]([CH3:3])[CH3:2])[C:9]1=[O:10])(=[O:17])[CH3:16]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 68142954HCID 68142954, compound

Product 1

HCID 21518736HCID 21518736, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To 9.0 parts sodium 3-isopropyl-6-methylthio-s-triazine-2,4(1H,3H)-dione prepared as in Example 10 in 100 parts tetrahydrofuran can be added 3.1 parts acetyl chloride. The reaction can be refluxed for 5 hours and the solvent evaporated. Methylene chloride can be added to the residue and the solution can be washed with 1N sodium hydroxide and brine. After drying and evaporation of the solvent, the residue can be recrystallized from chlorobutane.

Workup

  1. customThe reaction
  2. temperaturecan be refluxed for 5 hours
  3. customthe solvent evaporated
  4. additionMethylene chloride can be added to the residue
  5. washthe solution can be washed with 1N sodium hydroxide and brine
  6. customAfter drying
  7. customevaporation of the solvent
  8. customthe residue can be recrystallized from chlorobutane

Sources & evidence

ORD record
ord-e6e8dbf2efcb4752967d4ee2f247d7ec
Source dataset
uspto-grants-1976_08
Patent number
US03973947

Reaction notes

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