Water → HCID 171038878, compound

HRID 1282975Notes

Reaction equation

HRID 1282975 reaction equation
S(O)(O)(=O)=O.[CH3:6][O:7][C:8](=[NH:10])[NH2:9].O.[OH-].[Na+].[CH:14]([N:17]=[C:18]=[O:19])([CH3:16])[CH3:15]>CC(C)=O>[CH:14]([NH:17][C:18](=[O:19])[NH:10][C:8](=[NH:9])[O:7][CH3:6])([CH3:16])[CH3:15]

Participants

6

Reactant 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 61277Isopropyl isocyanateHCID 169039Carbamimidic acid, methyl ester, sulfate (1:1)

Product 1

HCID 171038878HCID 171038878, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To 114 parts of 2-methylpseudourea sulfate in 400 parts of water at 0°C is added 106 parts of 50% sodium hydroxide, followed by 400 parts of acetone, and 51 parts of isopropyl isocyanate. The reaction mixture is allowed to come to room temperature in 3 hrs. The organic solvent is then evaporated under vacuum, the aqueous residue saturated with sodium chloride, and the mixture extracted with methylene chloride. The organic extract is dried and the methylene chloride evaporated to yield 78 parts of methyl 4-isopropylallophanimidate, m.p. 64°-67°C.

Workup

  1. customThe organic solvent is then evaporated under vacuum
  2. extractionthe aqueous residue saturated with sodium chloride, and the mixture extracted with methylene chloride
  3. extractionThe organic extract
  4. customis dried
  5. customthe methylene chloride evaporated

Sources & evidence

ORD record
ord-5ea5c15131f149de91a3349c17309571
Source dataset
uspto-grants-1976_08
Patent number
US03973947

Reaction notes

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