o-Phenetidine → 2-(2-Ethoxyanilino)methyl-4-propylmorpholine toluene-p-sulphonate

Participants

Reaction Steps

A solution of 2-ethoxyaniline (4.8 g.) and 4-n-propyl-2-toluene-p-sulphonyloxymethylmorpholine (10 g.) in xylene (50 ml.) is heated under reflux in an atmosphere of nitrogen for 60 hours. A resinous solid separates from the solvent which is distilled under reduced pressure. The residual sticky solid is washed with ether to give a yellow solid which is crystallised from methanol/ether to give 2-(2-ethoxyanilino)methyl-4-propylmorpholine toluene-p-sulphonate, m.p. 169°-172°C.

Provenance & Evidence