反应详情

A solution of 2-ethoxyaniline (4.8 g.) and 4-n-propyl-2-toluene-p-sulphonyloxymethylmorpholine (10 g.) in xylene (50 ml.) is heated under reflux in an atmosphere of nitrogen for 60 hours. A resinous solid separates from the solvent which is distilled under reduced pressure. The residual sticky solid is washed with ether to give a yellow solid which is crystallised from methanol/ether to give 2-(2-ethoxyanilino)methyl-4-propylmorpholine toluene-p-sulphonate, m.p. 169°-172°C.

1. temperatureunder reflux in an atmosphere of nitrogen for 60 hours
2. distillationA resinous solid separates from the solvent which is distilled under reduced pressure
3. washThe residual sticky solid is washed with ether
4. customto give a yellow solid which
5. customis crystallised from methanol/ether