Hydrochloric Acid → HCID 21430384, compound

HRID 1283108Notes

Reaction equation

HRID 1283108 reaction equation
[ClH:1].C([N:5]([CH2:15][CH:16]1[O:21][CH2:20][CH2:19][NH:18][CH2:17]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[O:12][CH2:13][CH3:14])(=O)C.Cl.[OH-].[Na+]>>[ClH:1].[CH2:13]([O:12][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=1[NH:5][CH2:15][CH:16]1[O:21][CH2:20][CH2:19][NH:18][CH2:17]1)[CH3:14]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 21430364HCID 21430364, compound

Product 1

HCID 21430384HCID 21430384, compound

Procedure

A mixture of 2-(N-acetyl-2-ethoxyanilino)methylmorpholine hydrochloride (2 g.) and concentrated hydrochloric acid is heated under reflux for 24 hours. The solution is cooled, diluted with ice (25 g.), basified with sodium hydroxide solution and extracted with ether (2 × 100 ml.). The ether extract is dried (Na2SO4) and treated with ethereal HCl to give 2-(2-ethoxyanilino)methylmorpholine hydrochloride, m.p. 180°-181°C. on recrystallisation from ethanol.

Workup

  1. temperatureis heated
  2. temperatureunder reflux for 24 hours
  3. temperatureThe solution is cooled
  4. extractionextracted with ether (2 × 100 ml.)
  5. extractionThe ether extract
  6. dry with materialis dried (Na2SO4)
  7. additiontreated with ethereal HCl

Sources & evidence

ORD record
ord-3233d69d372b4e989ce8626ffe28b156
Source dataset
uspto-grants-1976_08
Patent number
US03974158

Reaction notes

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