HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → Ethyl 3,3-dicarbethoxy-4-(2-nitro-6-methylphenyl)butyrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Triethyl ethane-1,1,2-tricarboxylate | HCID 81961 | — |
| Reactant | 2-(chloromethyl)-1-methyl-3-nitroBenzene | HCID 12204070 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | Ethyl 3,3-dicarbethoxy-4-(2-nitro-6-methylphenyl)butyrate | HCID 21519363 | — |
Reaction Steps
The title compound was prepared by the same procedure as described in example 1 for 1a (R2 = R3 = H), using triethyl 1,1,2-ethanetricarboxylate (9.85 g; 0.04 mole), NaH (1.6 g; 0.04 mole) and 2-nitro-6-methylbenzyl chloride (7.4 g; 0.04 mole) in 20 ml. 10% dimethylformamide (DMF) in benzene. The crude product so obtained was used directly in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03974165 |
| Source dataset | uspto-grants-1976_08 |
| ORD ID | ord-75996b25040147648f413caddf8a64a0 |
| Source note | uspto-grants-1976_08 |