Hydrochloric Acid → HCID 21519265, compound

HRID 1283137Notes

Reaction equation

HRID 1283137 reaction equation
Cl.[CH3:2][CH:3]([C:11]1([OH:23])[CH2:16][CH2:15][CH2:14][CH2:13][CH:12]1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH2:4][N:5]1[CH2:10][CH2:9][O:8][CH2:7][CH2:6]1.[C:24]([Cl:27])(=[O:26])[CH3:25].[OH-].[Na+].Cl>CCOCC>[ClH:27].[C:24]([O:23][C:11]1([CH:3]([CH3:2])[CH2:4][N:5]2[CH2:10][CH2:9][O:8][CH2:7][CH2:6]2)[CH2:16][CH2:15][CH2:14][CH2:13][CH:12]1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)(=[O:26])[CH3:25]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 6367Acetyl chloride2×HCID 14798Sodium HydroxideHCID 21519287HCID 21519287, compound

Product 1

HCID 21519265HCID 21519265, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

1-(1-Methyl-2-morpholinoethyl)-2-phenylcyclohexanol hydrochloride (Example XVIII) is converted to the free base and treated with acetyl chloride according to the procedure of Example I (c) using 14 ml acetyl chloride and a reaction time of 90 hours. The product is treated with NaOH to give the base which is dissolved in ether and acidified with HCl gas to give 10.7 g., m. 176.5-7.5 after recrystallization from isopropanol.

Workup

  1. customa reaction time of 90 hours
  2. customto give the base which
  3. customto give 10.7 g
  4. custom176.5-7.5 after recrystallization from isopropanol

Sources & evidence

ORD record
ord-34cb46103967494191ad32c2aca5a87b
Source dataset
uspto-grants-1976_08
Patent number
US03974157

Reaction notes

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