Hydrochloric Acid → HCID 20498906, compound

HRID 128315Notes

Reaction equation

HRID 128315 reaction equation
[CH:1]1([CH2:7][NH:8][C:9]2[CH:21]=[CH:20][C:12]([CH2:13][CH2:14][C:15]([O:17]CC)=[O:16])=[CH:11][CH:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[OH-].[K+].C(O)C.Cl>O>[CH:1]1([CH2:7][NH:8][C:9]2[CH:21]=[CH:20][C:12]([CH2:13][CH2:14][C:15]([OH:17])=[O:16])=[CH:11][CH:10]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14797Potassium HydroxideHCID 20499027HCID 20499027, compound

Product 1

HCID 20498906HCID 20498906, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A 4 g. sample of ethyl 4-[(cyclohexyl)methylamino]-hydrocinnamate is hydrolyzed with 1.6 g. 85% potassium hydroxide in 60 ml. 95% ethanol by refluxing the solution for 5 hours. The solution is cooled, diluted with 100 ml. water and acidified to pH 4.5 with 37% hydrochloric acid. The precipitate is collected, dried in vacuo and crystallized from acetone to yield the title compound as white powder.

Workup

  1. temperatureThe solution is cooled
  2. additiondiluted with 100 ml
  3. customThe precipitate is collected
  4. customdried in vacuo
  5. customcrystallized from acetone

Sources & evidence

ORD record
ord-6d50a23bd3c549c8aad002bbc6448dcd
Source dataset
uspto-grants-1981_03
Patent number
US04259352

Reaction notes

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