反应详情

A mixture of 5.0 g. of ethyl 4-aminohydrocinnamate, 10.0 g. of 1-methanesulfonyloxy-2-allylcyclohexane (prepared by the method of Example 189), 4.2 g. of anhydrous powdered potassium carbonate and 40 ml. hexamethylphosphoramide is heated to 80 for 17 hours. The mixture is then cooled, diluted with water and extracted with ethyl ether. The ether extracts are washed with water, dried and evaporated. The residue is recrystallized from ethanol yielding the title compound as white crystals.

1. additionA mixture of 5.0 g
2. temperatureThe mixture is then cooled
3. extractionextracted with ethyl ether
4. washThe ether extracts are washed with water
5. customdried
6. customevaporated
7. customThe residue is recrystallized from ethanol yielding the title compound as white crystals