Trifluoroacetic acid → HCID 20498886, compound

HRID 128324Notes

Reaction equation

HRID 128324 reaction equation
FC(F)(F)C(O)=O.[OH-].[K+].[CH:10]1([CH:15]([NH:17][C:18]2[CH:38]=[CH:37][C:21]([C:22]([CH:24](C(OCC)=O)[C:25]([O:27][C:28](C)(C)[CH3:29])=[O:26])=[O:23])=[CH:20][CH:19]=2)[CH3:16])[CH2:14][CH2:13][CH2:12][CH2:11]1>>[CH:10]1([CH:15]([NH:17][C:18]2[CH:19]=[CH:20][C:21]([C:22]([CH2:24][C:25]([O:27][CH2:28][CH3:29])=[O:26])=[O:23])=[CH:37][CH:38]=2)[CH3:16])[CH2:14][CH2:13][CH2:12][CH2:11]1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 14797Potassium HydroxideHCID 20498921HCID 20498921, compound

Product 1

HCID 20498886HCID 20498886, compound

Procedure

A solution of 3.0 g. tert-butyl ethyl 4-(1-cyclopentylethylamino)benzoylmalonate 10 ml. of trifluoroacetic acid is warmed with stirring for 3 hours. The solution is poured onto ice and neutralized with potassium hydroxide. The resulting precipitate is collected by filtration, washed with water and dried. Recrystallization from chloroform affords ethyl 4-(1-cyclopentylethylamino)-benzoylacetate.

Workup

  1. filtrationThe resulting precipitate is collected by filtration
  2. washwashed with water
  3. customdried
  4. customRecrystallization from chloroform

Sources & evidence

ORD record
ord-b8c7fecc7b3643f1b0f6a9ded020fea4
Source dataset
uspto-grants-1981_03
Patent number
US04259352

Reaction notes

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