Hydrochloric Acid → HCID 20352418, compound

HRID 1283256Notes

Reaction equation

HRID 1283256 reaction equation
C([O:3][P:4]([C:7]1[CH:12]=[CH:11][C:10]([C:13]([O:15]CC)=[O:14])=[CH:9][CH:8]=1)([CH3:6])=[O:5])C.Cl>>[C:13]([C:10]1[CH:9]=[CH:8][C:7]([P:4]([CH3:6])(=[O:3])[OH:5])=[CH:12][CH:11]=1)([OH:15])=[O:14]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 70628361HCID 70628361, compound

Product 1

HCID 20352418HCID 20352418, compoundYield 86.4%

Procedure

200 g of p-ethoxycarbonylphenyl-methylphosphinic acid ethyl ester are refluxed with concentrated hydrochloride acid in excess. After the reaction is complete, the water and the hydrogen chloride are distilled off in a water jet pump vacuum. The residue is recrystallized from water. 135 g of p-carboxyphenyl-methylphosphinic acid having a melting point of 238°C to 240°C are obtained, corresponding to a yield of 87 90. ##SPC8##

Workup

  1. distillationthe water and the hydrogen chloride are distilled off in a water jet pump vacuum
  2. customThe residue is recrystallized from water

Sources & evidence

ORD record
ord-53bb5f37b4764658b35ded06ee89c56d
Source dataset
uspto-grants-1976_08
Patent number
US03974243

Reaction notes

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