Ethyl isothiocyanate → HCID 21519704, compound

HRID 1283267Notes

Reaction equation

HRID 1283267 reaction equation
[C:1]([C:5]1[CH2:6][CH2:7][NH:8][CH2:9][CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[CH2:11]([N:13]=[C:14]=[S:15])[CH3:12]>O1CCCC1>[CH2:11]([NH:13][C:14]([N:8]1[CH2:7][CH:6]=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[CH2:10][CH2:9]1)=[S:15])[CH3:12]

Participants

4

Reactant 2

HCID 10966Ethyl isothiocyanateHCID 215197034-tert-Butyl-1,2,3,6-tetrahydropyridine

Product 1

HCID 21519704HCID 21519704, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

In 20 ml. of anhydrous tetrahydrofuran there is dissolved 5.0 grams of 4-t-butyl-1,2,3,6-tetrahydropyridine. Stirring is initiated and there is added 3.14 grams of ethylisothiocyanate in 10 ml. of anhydrous tetrahydrofuran allowing the reaction to run at room temperature. After stirring the reaction mixture for 18 hours, the tetrahydrofuran is evaporated in vacuo to give N-ethyl-4-t-butyl-1,2,3,6-tetrahydro-1-pyridinethiocarboxamide.

Workup

  1. customto run at room temperature
  2. stirringAfter stirring the reaction mixture for 18 hours
  3. customthe tetrahydrofuran is evaporated in vacuo

Sources & evidence

ORD record
ord-ad7a2e1bbe2747feab55afc80d6d5c0b
Source dataset
uspto-grants-1976_08
Patent number
US03974283

Reaction notes

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