Allyl Isothiocyanate → HCID 21519702, compound

HRID 1283268Notes

Reaction equation

HRID 1283268 reaction equation
[C:1]([C:5]1[CH2:6][CH2:7][NH:8][CH2:9][CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[CH2:11]([N:14]=[C:15]=[S:16])[CH:12]=[CH2:13]>O1CCCC1>[CH2:11]([NH:14][C:15]([N:8]1[CH2:7][CH:6]=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[CH2:10][CH2:9]1)=[S:16])[CH:12]=[CH2:13]

Participants

4

Reactant 2

HCID 5971Allyl IsothiocyanateHCID 215197034-tert-Butyl-1,2,3,6-tetrahydropyridine

Product 1

HCID 21519702HCID 21519702, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

In 20 ml. of anhydrous tetrahydrofuran there is dissolved 5.0 grams of 4-t-butyl-1,2,3,6-tetrahydropyridine, and with stirring there is added 3.5 grams of allylisothiocyanate in 10 ml of anhydrous tetrahydrofuran. The reaction mixture is stirred for 24 hours at room temperature and the tetrahydrofuran is evaporated in vacuo. The resulting solid is dried at 50°C/20 mmHg. to remove any unreacted allylisothiocyanate to give N-allyl-4-t-butyl-1,2,3,6- -tetrahydro-1-pyridinethiocarboxamide.

Workup

  1. stirringThe reaction mixture is stirred for 24 hours at room temperature
  2. customthe tetrahydrofuran is evaporated in vacuo
  3. customThe resulting solid is dried at 50°C/20 mmHg
  4. customto remove any unreacted allylisothiocyanate

Sources & evidence

ORD record
ord-156cd34da4c54483b673ae5ca938c41d
Source dataset
uspto-grants-1976_08
Patent number
US03974283

Reaction notes

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