HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → 3-Hydroxypropyl 4-(2-cyclohexylethylamino)phenylacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 1,3-Propanediol | HCID 10442 | — |
| Reactant | Methyl 4-(2-cyclohexylethylamino)phenylacetate | HCID 20498942 | — |
| Product | 3-Hydroxypropyl 4-(2-cyclohexylethylamino)phenylacetate | HCID 20499014 | — |
Reaction Steps
A mixture of 2.25 g. of methyl 4-(2-cyclohexylethylamino)phenylacetate, 280 mg. of 1,3-propanediol and 1.37 g. p-toluenesulfonic acid is heated at 180° C. for 18 hours and then is partitioned between ether and 3% aqueous sodium carbonate solution. The ether layer is separated, dried, and evaporated to yield 3-hydroxypropyl 4-(2-cyclohexylethylamino)phenylacetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04259352 |
| Source dataset | uspto-grants-1981_03 |
| ORD ID | ord-8474239d58d143de978e66fb31dd317c |
| Source note | uspto-grants-1981_03 |