反应详情

温度

100 °C

2.57 g of 8-α-chloroethylcaffeine are dissolved in 25 ml of anhydrous dimethylformamide, to which 2.98 g of dry potassium nicotinate are added. The mixture is heated under shaking at 100° C for 1 hour, then filtered off and the filtrate evaporated under reduced pressure. The residue, after washing with water, gives 3.1 g of slightly crude product which is purified by crystallization from 95% ethanol : m.p. (EtOH) 160° C. The monohydrochloride melts at 200°-210° C.

1. additionare added
2. temperatureThe mixture is heated
3. filtrationfiltered off
4. customthe filtrate evaporated under reduced pressure
5. washThe residue, after washing with water
6. customgives 3.1 g of slightly crude product which
7. customis purified by crystallization from 95% ethanol
8. customm.p. (EtOH) 160° C