反应详情

A mixture of 4-[N-trifluoroacetyl-(2-cyclohexylethylamino)]phenylacetyl chloride and 1.2 g. triethylamine in 100 ml. warm ether is treated with 2.5 g. diethyl tartrate and refluxed for 24 hours. The hot solution is filtered, the residue is washed with hot ether, and the solution is evaporated. After treatment with aqueous methanolic potassium carbonate, the product is precipitated by acidification, filtered, and dried. Crystallization from acetone yields diethyl O-[4-(2-cyclohexylethylamino)phenylacetyl]-tartrate as a white, crystalline solid.

1. filtrationThe hot solution is filtered
2. washthe residue is washed with hot ether
3. customthe solution is evaporated
4. customAfter treatment with aqueous methanolic potassium carbonate, the product is precipitated by acidification
5. filtrationfiltered
6. customdried
7. customCrystallization from acetone