4-Chloro-3-nitrobenzophenone → [4-(4-Methylpiperazin-1-yl)-3-nitrophenyl](phenyl)methanone

HRID 1283391Notes

Reaction equation

[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[N+:8]([C:11]1[CH:12]=[C:13]([CH:22]=[CH:23][C:24]=1Cl)[C:14]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:15])([O-:10])=[O:9]>>[N+:8]([C:11]1[CH:12]=[C:13]([CH:22]=[CH:23][C:24]=1[N:5]1[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]1)[C:14]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:15])([O-:10])=[O:9]

Participants

Reactant 2

HCID 417434-Chloro-3-nitrobenzophenone

HCID 531671-Methylpiperazine

Product 1

HCID 2905641[4-(4-Methylpiperazin-1-yl)-3-nitrophenyl](phenyl)methanoneYield 90%

Procedure

N-methyl-piperazine is reacted with 3-nitro-4-chloro-benzophenone as described in Example 7 or 8 to obtain 3-nitro-4-(N-methyl-piperazino)-benzophenone with a yield of 90 %. The product melts at 94 °C.

Sources & evidence

ORD record: ord-49483b5aa8ae4bb38407e3ac54fe536d
Source dataset: uspto-grants-1976_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03975390

Reaction notes

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